Ipswich, Brisbane, Logan, Redlands and Moreton Bay will go into a three-day lockdown from 5pm Monday, March 29 with masks compulsory for anyone in those areas when leaving the house.
The announcement came after Queensland recorded ten new Covid-19 cases overnight, four locally acquired.
Premier Annastacia Palaszczuk said two of the four locally acquired cases had already been linked.
"Two are known cases of one of the previous people, then we have two under investigation but we believe one of them is a nurse from the PA hospital," Ms Palaszczuk said.
Ms Palaszczuk the lockdown was necessary as the virus was the UK strain.
“This is essential that we do this so that we stop further transmission,” she said.
“I know this is a big call, I know this is very tough, we’ve got Easter coming up, we’ve got school holidays coming but let’s do it now and let’s do it right.”
People in Greater Brisbane will only be able to leave their homes for four essential reasons, grocery shopping, exercise, work and medical care.
Schools will also close from tomorrow however will remain available for children of essential workers, only two visitors will be allowed at homes and only two visitors will be allowed at homes.
Hospitality venues such as cafes and restaurants will only be able to offer takeaway.
Queensland Health specified all Queenslanders must carry a face mask with them at all times when leaving home unless they have a lawful reason not to and they must be worn in indoor places outside the home.
Unlike the last Greater Brisbane lockdown, masks are not required to be worn in a private vehicle, but they are required in rideshare vehicles, public transport and taxis.
Changes in courts across the five hotspot council areas will also come into play from Monday evening.
Magistrates courts in Ipswich along with other locations in the Greater Brisbane region will close their registries to the public from Monday afternoon.
Physical appearances will not be mandatory throughout the three-day lockdown and all matters are set to be heard via telephone or video conference with all hearings to be adjourned.
The District and Supreme courts in Ipswich, Brisbane and Beenleigh will halt new juries and sentences will progress via video link.
Wedding ceremonies have been restricted to a maximum of 10 people, including celebrant and witnesses.
Funerals are restricted to a maximum of 20 people, excluding officials.
Queensland Health advises because of restrictions on non-essential businesses, wedding receptions or other events post weddings and funerals should be postponed.
Chief Health Officer Dr Jeannette Young said Queenslanders outside Greater Brisbane will also have restrictions put in place due to movement of the confirmed cases, one man travelling to Gladstone and two cases travelling to Byron Bay.
“Anyone who has been in the Greater Brisbane area since Saturday, March 20 is now required to follow those same requirements.
“And anyone outside Greater Brisbane, those five local government areas has also had restrictions placed upon them.
“We will also be limiting visits to aged care, to disability accommodation services, to hospitals and to prisons.
“People can only have gatherings in their own homes of up to 30 people.”
Outside of Greater Brisbane, Queenslanders will also be required to be worn when they are unable to physically distance.
Hospitality workplaces outside of the hotspot will be only able to offer seated dine in with no food or drink orders to be taken at the counter.
The lockdown will be reviewed on Wednesday night.
